Can Low Vitamin D Cause Fainting

Can Low Vitamin D Cause Fainting

. 2020 Feb 10;36(2):371-376.

doi: 10.1002/joa3.12309. eCollection 2020 Apr.

Is there any link between vitamin D deficiency and vasovagal syncope?

Affiliations

• PMID: 32256891
• PMCID: PMC7132194
• DOI: 10.1002/joa3.12309

Free PMC article

Is there any link between vitamin D deficiency and vasovagal syncope?

Songül Usalp  et al. J Arrhythm. 2020 .

Free PMC article

Abstract

Background: This study aimed to investigate serum 25[OH]D levels between patients with vasovagal syncope (VVS) diagnosed with head-up tilt table test (HUTT) and age-matched healthy people.

Methods: The study included 75 consecutive patients (32.3 ± 10.7 years), who presented with syncope and underwent HUTT and 52 healthy controls (32.9 ± 14.1 years). HUTT patients were divided into two groups according to whether there was syncope response to the test. Patients underwent cardiac, psychiatric, and neurological investigation. Serum 25[OH]D levels were measured by chemiluminescent microparticle immunoassay method.

Results: There was no difference between the two groups in terms of age, gender, body mass index (BMI), echocardiographic findings (P > .05). Mean serum 25[OH]D (24.5 ± 6.3 vs 20.1 ± 8.8 ng/mL, P = .003) and vitamin B12 levels (436.4 ± 199.2 vs 363.1 ± 107.6 pg/mL, P = .009) was lower in syncope patients when compared to the control group. In correlation analyses, syncope was shown as correlated with the vitamin D (r = -264, P = .003) and vitamin B12 levels (r = -233, P = .009). But, multivariate regression analyses showed that only vitamin D increased risk of syncope [OR: 0.946, 95% CI (0.901-0.994)]. There was no difference in terms of age, gender, BMI, echocardiographic findings between the in HUTT positive (n = 45) and negative groups (n = 29). Only vitamin D level was significantly lower in HUTT positive group (17.5 ± 7.7 vs 24.4 ± 9.1 ng/mL, P = .002). There was no difference among in the vasovagal subgroups in terms of vitamin D level and other features.

Conclusion: Vitamin D and B12 levels were reasonably low in syncope patients, but especially low Vitamin D levels were associated with VVS diagnosed in HUTT.

Keywords: head‐up tilt table test; syncope; vitamin D deficiency.

© 2020 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Heart Rhythm Society.

Conflict of interest statement

Authors declare no conflict of interests for this article. Written informed consent was obtained from all patients before participating in the study

Figures

Figure 1

Flowchart of the number of patients included in the study

Figure 2

Vitamin D levels between head‐up tilt test (HUTT) positive and negative

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Can Low Vitamin D Cause Fainting

Source: https://pubmed.ncbi.nlm.nih.gov/32256891/